Yearly Archives: 2017

NEW PAPERS!

We published some new articles.   Neighborhood watch – Professional journal club: High-molecular-weight kininogen: breaking bad in lethal endotoxemia. Hofman ZLM, De Maat S, Maas C. J Thromb Haemost. 2017 Dec 11. doi: 10.1111/jth.13924. [Epub ahead of print]   With one of my personal contact system “heroes”: The Search for Biomarkers in Hereditary Angioedema. Kaplan AP, Maas C. Front Med (Lausanne). 2017 Nov 22;4:206. doi: 10.3389/fmed.2017.00206. With our esteemed former colleague Claudia: Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice. Tersteeg C, Joly BS, Gils A, Lijnen…

NEW PAPER! Hofman et al. – Cleaved kininogen as a biomarker for bradykinin release in hereditary angioedema

Zonne Hofman has done it! She published her solution to a diagnostic problem in the Journal of Allergy and Clinical Immunology. Bradykinin is a powerful inflammatory molecule, but nearly impossible to measure in the blood of patients, because it is rapidly degraded. We looked whether we could detect changes in the ‘parent molecule’ kininogen that take place during bradykinin production with home-made nanobodies. In the end, we developed a bio-assay (let’s call it the Kalli-cHK assay) that is able to quantify cHK levels in blood plasma of patients with hereditary…

Research Grant from Trombosestichting Nederland

I recently received some amazing news in the middle of the great funding massacre that nearly killed me only a few days earlier. My project “Nature’s Nanoparticles” was granted funding by Trombosestichting Nederland! I am very thankful! This means that we can investigate the properties of platelet polyphosphate nanoparticles in health and cardiovascular disease. I believe that polyphosphate nanoparticles are the ‘cement’ that keeps the bricks (cells) of a blood clot together (drawn below). If a blood clot is torn apart, this material is exposed to the blood stream, calling in…

New paper! Barendrecht et al. – Live-cell Imaging of Platelet Degranulation and Secretion Under Flow.

We recently made a video with JoVE (Journal of Visualized Experiments). It was really fun! You can find the movie and paper here. It took me quite some time to prepare the ‘movie-script’ (really different than writing a normal publication), but it does count as a real publication on pubmed! Arjan and Silvia organized the ‘show’ on the filming day (impressively organized) and all of us had to say a few words. I was reminded how terrible I am in front of a camera! It was much more comfortable to…

Crystals on the surface of cells

We just published our latest discovery. There’s crystals on the surface of cells! You can find them in this week’s issue of Blood (Link). An image from our paper made it to the cover, there was a very nice commentary written about it (Link) and it was selected as one of the issue highlights. Yeah, these crystalline particles are beautiful by themselves (at least, I think so), but like the double-rainbow guy asks: “What does it all mean?” We think they form some kind of scaffold for molecular interaction. In the…