NEW PAPER! Hofman et al. – Cleaved kininogen as a biomarker for bradykinin release in hereditary angioedema

Zonne Hofman has done it! She published her solution to a diagnostic problem in the Journal of Allergy and Clinical Immunology.
Bradykinin is a powerful inflammatory molecule, but nearly impossible to measure in the blood of patients, because it is rapidly degraded. We looked whether we could detect changes in the ‘parent molecule’ kininogen that take place during bradykinin production with home-made nanobodies. In the end, we developed a bio-assay (let’s call it the Kalli-cHK assay) that is able to quantify cHK levels in blood plasma of patients with hereditary angioedema (HAE).
This is going to be a catalyst for clinical research on HAE, as well as many other inflammatory conditions in which bradykinin is a prime suspect!

You can find the paper here.

Assay principle

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